Clinical Characterization of Patients with Sporadic Creutzfeldt-Jakob Disease Treated at a High-Complexity Hospital in Bogotá Between 2013 and 2025

Introduction: Diagnosing CJD remains challenging because no single definitive test exists during life. It relies on a
combination of clinical and imaging findings. Despite diagnostic advances over the past two decades, access to
these technologies is limited in many Latin American settings, including Colombia.
Methods: Descriptive observational case-series study. Findings will be presented for patients diagnosed with
sporadic Creutzfeldt-Jakob disease—classified as possible, probable, or definite according to WHO criteria—who
were treated at a tertiary-care hospital in Colombia between 2013 and 2025. Demographic and clinical variables,
imaging findings, and electroencephalographic patterns will be recorded and summarized using descriptive
statistics.

To characterize the clinical manifestations, imaging findings, and electroencephalographic patterns in patients diagnosed with sporadic Creutzfeldt-Jakob disease at a tertiary-care hospital in Colombia between 2013 and 2025.

A cohort of Colombian patients with Creutzfeldt-Jakob disease will be characterized, enabling clarification of the predominant phenotype in the country; the findings will be disseminated through publications of national and international scope.