Creating and validating a warfarin pharmacogenetic dosing algorithm for Colombian patients

  • Fonseca-Mendoza, Dora Janeth (CoI)
  • Galvez, Jubby Marcela (PI)
  • Restrepo, Carlos Martín (PI)
  • Contreras Bravo, Nora Constanza (CoI)
  • Calderón-Ospina, Carlos Alberto (CoI)
  • Laissue, Paul (CoI)
  • Cifuentes, Ricardo A (CoI)

Project Details


Warfarin is an oral anticoagulant associated with adverse reaction to drugs due to wide inter- and intra-individual dosage variability. Warfarin dosage has been related to non-genetic and genetic factors. CYP2C9 and VKORC1 gene polymorphisms affect warfarin metabolism and dosage. Due to the central role of populations’ ethnical and genetic origin on warfarin dosage variability, novel algorithms for Latin American subgroups are necessary to establish safe anticoagulation therapy.
Effective start/end date1/04/161/04/18

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being


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