Fatal co-infection by multiple pathogens in an indigenous woman with miliary tuberculosis

  • Firacative, Carolina (PI)
  • Tabares, Bryan (CoPI)
  • Sarmiento, Alisson (CoI)
  • Gil Montoya, Óscar (CoI)
  • Hernández-Pabón, Juan Camilo (CoI)

Project Details

Description

Tuberculosis (TB), one of the leading causes of death worldwide, has a higher incidence among indigenous people. Miliary TB, an extrapulmonary form of TB, can cause multiple complications including autoimmune hemolytic anemia (AIHA) and secondary infections. Here we present a case of an indigenous woman from Colombia with miliary TB who presented with AIHA. Despite multiple treatments, therapies and medical interventions, the patient died after a severe medullary aplasia of multiple causes, including secondary myelotoxicity by immunosuppressive therapy and secondary disseminated infections by multiple pathogens, which together led to significant clinical complications. Co-infection with Staphylococcus aureus, Enterococcus faecium, Klebsiella pneumoniae and Candida glabrata, which were identified as drug-resistant microorganisms, further hindered treatment. This report highlights the great challenges of dealing with co-infections by resistant pathogens and aims to spur governments and public health authorities to focus attention in the prevention and management of TB, especially among vulnerable communities.
StatusFinished
Effective start/end date25/09/2325/09/24

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 10 - Reduced Inequalities

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