Impact of mammoglobin expression levels on transcriptional deregulation of microRNAs and their clinical application in breast cancer

This project aims to establish whether different levels of mammoglobin expression in mammary tumors have an impact on the deregulation of miRNA expression leading to the generation of a new tumor subclassification.
Formaldehyde-fixed and paraffin-embedded samples from 40 patients will be used for RNA extraction and the expression of mammoglobin by qPCR and that of miRNAs by the Ilumina platform will be evaluated. The results will be analyzed by statistical and bioinformatic tests.
It is hoped to obtain a list of genes coding for miRNAs deregulated by mammoglobin expression levels, which could contribute to a new subclassification of mammary tumors.