Study of the Intestinal Microbiome and Circulating microRNAome in the Natural History of Colorectal Cancer for the Identification of Biomarkers with Potential Use in Screening for This Disease in Bogotá, Colombia

  • Combita Rojas, Allba Lucía (PI)
  • Wiesner Ceballos, Carolina (CoI)
  • Murillo, Raúl Hernando (CoI)
  • Torres Ibarguen , Miguel Zamir (CoI)
  • Montero Valle, Wendy Johana (CoI)
  • Rey Vargas, Laura (CoI)
  • Escobar Pérez, Javier Antonio (CoI)
  • Abril Riaño, Deisy Julieth (CoI)
  • Prada Gómez, Luisa Fernanda (CoI)
  • Rendón Hernández, Martha Juliana (CoI)
  • Serrano López , Martha Lucia (CoI)
  • Mesa López de Mesa, Jorge Andrés (CoI)
  • Figueroa Avendano, Carlos (CoPI)
  • Cala-Noriega, Juan Guillermo (CoI)

Project Details

Description

Colorectal cancer (CRC) is a public health issue both globally and in Colombia, and its incidence is on the rise. Screening with fecal occult blood testing (FOBT), followed by colonoscopy, is currently used as a method for early detection. Despite the availability of screening tests, the mortality rate for this type of cancer remains high. FOBT falls short of the desired performance, although an improved test using immunochemical detection (FIT) is now being implemented.

Objective

To study the intestinal microbiome and circulating microRNAome in the natural history of colorectal cancer for the identification of biomarkers with potential utility in screening for this disease in Bogotá, Colombia

Key findings

To generate knowledge about the potential of the microbiome and microRNAs as screening biomarkers for colorectal cancer (CRC). Additionally, to strengthen an interinstitutional research line in microbiome and CRC, microRNAs and cancer, enabling multidisciplinary participation and a country-level approach.
StatusActive
Effective start/end date20/03/2520/03/27

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Mederi Institutes

  • Cancer Institute
  • Complex Abdominal Pathology Institute

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