Colombian consensus for the prevention, diagnosis and treatment of thrombotic conditions in adults with COVID-19: applying GRADE Evidence to Decision (EtD) Frameworks

Translated title of the contribution: Colombian consensus for the prevention, diagnosis and treatment of thrombotic conditions in adults with COVID-19: applying GRADE Evidence to Decision (EtD) Frameworks

Juan Acevedo-Peña, Nancy Yomayusa-González, Francy Cantor-Cruz, Carlos Pinzón-Flórez, Liliana Barrero-Garzón, Ilich De-La-Hoz-Siegler, Eduardo Low-Padilla, Carlos Ramírez-Cerón, Felipe Combariza-Vallejo, Carlos Arias-Barrera, Javier Moreno-Cortés, José Rozo-Vanstrahlen, Liliana Correa-Pérez, José Rojas-Gambasica, Camilo González-González, Eduardo La-Rotta-Caballero, Paula Ruíz-Talero, Rubén Contreras-Páez, Alberto Lineros-Montañez, Jorge Ordoñez-CardalesMario Escobar-Olaya, Raúl Izaguirre-Ávila, Joao Campos-Guerra, José Accini-Mendoza, Camilo Pizarro-Gómez, Adulkarín Patiño-Pérez, Janine Flores-Rodríguez, Albert Valencia-Moreno, Alejandro Londoño-Villegas, Alfredo Saavedra-Rodríguez, Ana Madera-Rojas, Andrés Caballero-Arteagam, Andrés Díaz-Campos, Felipe Correa-Rivera, Andrés Mantilla-Reinaud, Ángela Becerra-Torres, Ángela Peña-Castellanos, Aura Reina-Soler, Bibiana Escobar-Suarez, Bonell Patiño-Escobar, Camilo Rodríguez-Cortés, Carlos Rebolledo-Maldonado, Carlos Ocampo-Botero, Carlos Rivera-Ordoñez, Carlos Saavedra-Trujillo, Catalina Figueroa-Restrepo, Claudia Agudelo-López, Claudia Jaramillo-Villegas, Claudio Villaquirán-Torres, Daniel Rodríguez-Ariza, David Rincón-Valenzuela, Melissa Lemus-Rojas, Diego Pinto-Pinzón, Diego Garzón-Díaz, Diego Cubillos-Apolinar, Edgar Beltrán-Linares, Emilio Kondo-Rodríguez, Erica Yama-Mosquera, Ernesto Polania-Fierro, Evalo Real-Urbina, Andrés Rosas-Romero, Fernán Mendoza-Beltrán, Fredy Guevara-Pulido, Gina Celia-Márquez, Gloria Ramos-Ramos, Gonzalo Prada-Martínez, Guillermo León-Basantes, Guillermo Liévano-Sánchez, Guillermo Ortíz-Ruíz, Gustavo Barreto-García, Harold Ibagón-Nieto, Henry Idrobo-Quintero, Ingrid Martínez-Ramírez, Ivan Solarte-Rodríguez, Jorge Quintero-Barrios, Jaime Arenas-Gamboa, Jairo Pérez-Cely, Jeffrey Castellanos-Parada, Fredy Garzón-Martínez, Joaquín Luna-Ríos, Joffre Lara-Terán, Johanna Vargas-Rodríguez, Rubén Dueñas-Villamil, Vicente Bohórquez-Reyes, Carlos Martínez-Acosta, Esteban Gómez-Mesa, Julián Gaitán-Rozo, Julián Cortes-Colorado, Juliana Coral-Casas, Laura Horlandy-Gómez, Leonardo Bautista-Toloza, Leonardo Palacios Palacios, Lina Fajardo-Latorre, Luis Pino-Villarreal, Leonardo Rojas-Puentes, Patricia Rodríguez-Sánchez, Mauricio Herrera-Méndez, Mauricio Orozco-Levi, Mónica Sosa-Briceño, Nelson Moreno-Ruíz, Oscar Sáenz-Morales, Pablo Amaya-González, Sergio Ramírez-García, Víctor Nieto-Estrada, Virgil Carballo-Zárate, Virginia Abello-Polo

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Introduction: recent studies have reported the occurrence of thrombotic phenomena or coagulopathy in patients with COVID-19. There are divergent positions regarding the prevention, diagnosis, and treatment of these phenomena, and current clinical practice is based solely on deductions by extension from retrospective studies, case series, observational studies, and international guidelines developed prior to the pandemic. Objective: to generate a group of recommendations on the prevention, diagnosis and management of thrombotic complications associated with COVID-19. Methods: a rapid guidance was carried out applying the GRADE Evidence to Decision (EtD) frameworks and an iterative participation system, with statistical and qualitative analysis. Results: 31 clinical recommendations were generated focused on: a) Coagulation tests in symptomatic adults with suspected infection or confirmed SARS CoV-2 infection; b) Thromboprophylaxis in adults diagnosed with COVID-19 (Risk scales, thromboprophylaxis for outpatient, in-hospital management, and duration of thromboprophylaxis after discharge from hospitalization), c) Diagnosis and treatment of thrombotic complications, and d) Management of people with previous indication of anticoagulant agents. Conclusions: recommendations of this consensus guide clinical decision-making regarding the prevention, diagnosis, and treatment of thrombotic phenomena in patients with COVID-19, and represent an agreement that will help decrease the dispersion in clinical practices according to the challenge imposed by the pandemic.

Translated title of the contributionColombian consensus for the prevention, diagnosis and treatment of thrombotic conditions in adults with COVID-19: applying GRADE Evidence to Decision (EtD) Frameworks
Original languageEnglish
Pages (from-to)446-460
Number of pages15
JournalRevista Colombiana de Cardiologia
Volume27
Issue number5
DOIs
StatePublished - 1 Sep 2020

Keywords

  • Anticoagulants
  • COVID-19
  • Consensus
  • Embolism and thrombosis
  • SARS CoV-2

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