Cross-cultural adaptation of the cambridge pulmonary hypertension outcome review for use in patients with pulmonary hypertension in Colombia

Claudio Villaquirán, Socorro Moreno, Rubén Dueñas, Paola Acuña, Juan Ricardo Lutz, Jeanette Wilburn, Alice Heaney

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3 Scopus citations


Objective: To conduct a cross-cultural adaptation of the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) as an instrument to evaluate the perception of symptoms, functional limitation, and health-related quality of life (HRQoL) in subjects diagnosed with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH) in Colombia. Methods: The adaptation process involved 3 phases: Translation, cognitive debriefing interviews, and a validation survey. To evaluate the psychometric properties, we recruited individuals ≥ 18 years of age who had been diagnosed with PAH or CTEPH to take part in the latter two stages of the adaptation process. All individuals were being followed on an outpatient basis by the pulmonary hypertension programs at Hospital Universitario San Ignacio, Fundación Clínica Shaio,and Clínicos IPS, all located in the city of Bogotá, Colombia. Results: A Spanish-language version of the CAMPHOR was developed for use in Colombia. The internal consistency was excellent for the symptoms, functioning, and quality of life scales ( Cronbach’s alpha c oefficients of 0.92, 0.87, and 0.93, respectively). T estretest reliability was above 0.70. The evaluation of the convergent validity and known group validity of the CAMPHOR scales confirmed that there were moderate and strong correlations with the related constructs of the Medical Outcomes Study 36-item Short-Form Health Survey, version 2, as well as showing their capacity to discriminate disease severity. Conclusions: The Spanish-language version of the CAMPHOR developed for use in Colombia was the result of a translation and cultural adaptation process that allows us to consider it equivalent to the original version, having shown good psychometric properties in the study sample. Therefore, its use to assess the impact of interventions on the HRQoL of patients with PAH or CTEPH is recommended, in research and clinical practice.

Original languageEnglish
Article numbere20180332
JournalJornal Brasileiro de Pneumologia
Issue number6
StatePublished - 2019
Externally publishedYes


  • Hypertension
  • Psychometrics
  • Pulmonary
  • Pulmonary embolism
  • Quality of life


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