TY - JOUR
T1 - Development of Antiepileptic Drugs throughout History
T2 - From Serendipity to Artificial Intelligence
AU - Corrales-Hernández, María Gabriela
AU - Villarroel-Hagemann, Sebastián Kurt
AU - Mendoza-Rodelo, Isabella Esther
AU - Palacios-Sánchez, Leonardo
AU - Gaviria-Carrillo, Mariana
AU - Buitrago-Ricaurte, Natalia
AU - Espinosa-Lugo, Santiago
AU - Calderon-Ospina, Carlos-Alberto
AU - Rodríguez-Quintana, Jesús Hernán
PY - 2023/6/3
Y1 - 2023/6/3
N2 - This article provides a comprehensive narrative review of the history of antiepileptic drugs (AEDs) and their development over time. Firstly, it explores the significant role of serendipity in the discovery of essential AEDs that continue to be used today, such as phenobarbital and valproic acid. Subsequently, it delves into the historical progression of crucial preclinical models employed in the development of novel AEDs, including the maximal electroshock stimulation test, pentylenetetrazol-induced test, kindling models, and other animal models. Moving forward, a concise overview of the clinical advancement of major AEDs is provided, highlighting the initial milestones and the subsequent refinement of this process in recent decades, in line with the emergence of evidence-based medicine and the implementation of increasingly rigorous controlled clinical trials. Lastly, the article explores the contributions of artificial intelligence, while also offering recommendations and discussing future perspectives for the development of new AEDs.
AB - This article provides a comprehensive narrative review of the history of antiepileptic drugs (AEDs) and their development over time. Firstly, it explores the significant role of serendipity in the discovery of essential AEDs that continue to be used today, such as phenobarbital and valproic acid. Subsequently, it delves into the historical progression of crucial preclinical models employed in the development of novel AEDs, including the maximal electroshock stimulation test, pentylenetetrazol-induced test, kindling models, and other animal models. Moving forward, a concise overview of the clinical advancement of major AEDs is provided, highlighting the initial milestones and the subsequent refinement of this process in recent decades, in line with the emergence of evidence-based medicine and the implementation of increasingly rigorous controlled clinical trials. Lastly, the article explores the contributions of artificial intelligence, while also offering recommendations and discussing future perspectives for the development of new AEDs.
U2 - 10.3390/biomedicines11061632
DO - 10.3390/biomedicines11061632
M3 - Artículo de revisión
C2 - 37371727
SN - 2227-9059
VL - 11
JO - Biomedicines
JF - Biomedicines
IS - 6
ER -