TY - JOUR
T1 - Early mobilisation in patients with shock and receiving vasoactive drugs in the intensive care unit
T2 - A systematic review and meta-analysis of observational studies
AU - Parada-Gereda, Henry Mauricio
AU - Pardo-Cocuy, Luis Fernando
AU - Avendaño, Janneth Milena
AU - Molano-Franco, Daniel
AU - Masclans, Joan Ramón
N1 - Copyright © 2024 Elsevier España, S.L.U. and SEMICYUC. All rights reserved.
PY - 2025/4
Y1 - 2025/4
N2 - OBJECTIVE: The aim of the study was to assess the feasibility and safety of early mobilisation in patients with shock requiring vasoactive drugs in the intensive care unit (ICU).DESIGN: Systematic review and meta-analysis.SETTING: Intensive care unit (ICU).PATIENTS OR PARTICIPANTS: Adult patients requiring vasoactive drugs who received early mobilisation in the intensive care unit.INTERVENTIONS: A systematic search was conducted using the databases PubMed, Cochrane Library, Scopus, Medline Ovid, Science Direct, and CINAHL, including observational studies involving adult patients requiring vasoactive drugs who received early mobilisation. A meta-analysis was performed on the proportion of safety events and the proportion of early mobilisation in patients with high, moderate, and low doses of vasoactive drugs.MAIN VARIABLES OF INTEREST: Feasibility, safety events, and the maximum level of activity achieved during early mobilisation.RESULTS: The search yielded 1875 studies, of which 8 were included in the systematic review and 5 in the meta-analysis. The results showed that 64% (95% CI: 34%-95%, p<0.05) of patients were mobilised with low doses of vasoactive drugs, 30% (95% CI: 7%-53%, p<0.05) with moderate doses, and 7% (95% CI: 3%-16%, p 0.17) with high doses. The proportion of adverse events was low, at 2% (95% CI: 1%-4%, p<0.05).CONCLUSIONS: Early mobilisation in patients with shock and the need for vasoactive drugs is feasible and generally safe. However, there is an emphasis on the need for further high-quality research to confirm these findings.
AB - OBJECTIVE: The aim of the study was to assess the feasibility and safety of early mobilisation in patients with shock requiring vasoactive drugs in the intensive care unit (ICU).DESIGN: Systematic review and meta-analysis.SETTING: Intensive care unit (ICU).PATIENTS OR PARTICIPANTS: Adult patients requiring vasoactive drugs who received early mobilisation in the intensive care unit.INTERVENTIONS: A systematic search was conducted using the databases PubMed, Cochrane Library, Scopus, Medline Ovid, Science Direct, and CINAHL, including observational studies involving adult patients requiring vasoactive drugs who received early mobilisation. A meta-analysis was performed on the proportion of safety events and the proportion of early mobilisation in patients with high, moderate, and low doses of vasoactive drugs.MAIN VARIABLES OF INTEREST: Feasibility, safety events, and the maximum level of activity achieved during early mobilisation.RESULTS: The search yielded 1875 studies, of which 8 were included in the systematic review and 5 in the meta-analysis. The results showed that 64% (95% CI: 34%-95%, p<0.05) of patients were mobilised with low doses of vasoactive drugs, 30% (95% CI: 7%-53%, p<0.05) with moderate doses, and 7% (95% CI: 3%-16%, p 0.17) with high doses. The proportion of adverse events was low, at 2% (95% CI: 1%-4%, p<0.05).CONCLUSIONS: Early mobilisation in patients with shock and the need for vasoactive drugs is feasible and generally safe. However, there is an emphasis on the need for further high-quality research to confirm these findings.
KW - Humans
KW - Intensive Care Units
KW - Observational Studies as Topic
KW - Early Ambulation/adverse effects
KW - Vasoconstrictor Agents/therapeutic use
KW - Shock/drug therapy
KW - Critical Care/methods
KW - Feasibility Studies
U2 - 10.1016/j.medine.2024.09.013
DO - 10.1016/j.medine.2024.09.013
M3 - Artículo de revisión
C2 - 39551690
SN - 2173-5727
VL - 49
SP - 193
EP - 204
JO - Medicina intensiva
JF - Medicina intensiva
IS - 4
ER -
