Electrophysiological Biomarkers in Dual Pathology

Translated title of the contribution: Electrophysiological Biomarkers in Dual Pathology

Luz Angela Rojas Bernal, Hernando Santamaría García, Guillermo Alonso Castaño Pérez

Research output: Contribution to journalReview articlepeer-review


Introduction: The co-occurrence of substance use disorder with at least one other mental disorder is called dual pathology, which in turn is characterised by heterogeneous symptoms that are difficult to diagnose and have a poor response to treatment. For this reason, the identification and validation of biomarkers is necessary. Within this group, possible electroencephalographic biomarkers have been reported to be useful in diagnosis, treatment and follow-up, both in neuropsychiatric conditions and in substance use disorders. This article aims to review the existing literature on electroencephalographic biomarkers in dual pathology. Methods: A narrative review of the literature. A bibliographic search was performed on the PubMed, Science Direct, OVID, BIREME and Scielo databases, with the key**words: electrophysiological biomarker and substance use disorder, electrophysiological biomarker and mental disorders, biomarker and dual pathology, biomarker and substance use disorder, electroencephalography, and substance use disorder or comorbid mental disorder. Results: Given the greater amount of literature found in relation to electroencephalography as a biomarker of mental illness and substance use disorders, and the few articles found on dual pathology, the evidence is organised as a biomarker in psychiatry for the diagnosis and prediction of risk and as a biomarker for dual pathology. Conclusions: Although the evidence is not conclusive, it suggests the existence of a subset of sites and mechanisms where the effects of psychoactive substances and the neurobiology of some mental disorders could overlap or interact.

Translated title of the contributionElectrophysiological Biomarkers in Dual Pathology
Original languageEnglish
JournalRevista Colombiana de Psiquiatria
StateAccepted/In press - 2022
Externally publishedYes


  • Biomarkers
  • Dual pathology
  • Electroencephalography
  • Mental disorders
  • Substance-related disorders


Dive into the research topics of 'Electrophysiological Biomarkers in Dual Pathology'. Together they form a unique fingerprint.

Cite this