Impact of a Basal-Bolus Insulin Regimen on Metabolic Control and Risk of Hypoglycemia in Patients With Diabetes Undergoing Peritoneal Dialysis

Ana María Gómez, Santiago Vallejo, Freddy Ardila, Oscar M. Muñoz, Álvaro J. Ruiz, Mauricio Sanabria, Alfonso Bunch, Elly Morros, Laura Kattah, Maira García-Jaramillo, Fabián León-Vargas

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Introduction: Clinical interventional studies in diabetes mellitus usually exclude patients undergoing peritoneal dialysis (PD). This study evaluates the impact of an educational program and a basal-bolus insulin regimen on the blood glucose level control and risk of hypoglycemia in this population. Methods: A before-and-after study was conducted in type 1 and type 2 DM patients undergoing PD at the Renal Therapy Services (RTS) clinic network, Bogota, Colombia. An intervention was instituted consisting of a three-month educational program and a basal-bolus detemir (Levemir, NovoNordisk) and aspart (Novorapid, NovoNordisk) insulin regimen. Prior to the intervention and at the end of treatment were conducted measures of HbA1c levels and continuous glucose monitoring (CGM). Results: Forty-seven patients were recruited. Mean HbA1c level decreased from 8.41% ± 0.83 to 7.68% ± 1.32 (mean difference −0.739, 95% CI −0.419, −1.059; P <.0001). Of subjects, 52% achieved HbA1c levels <7.5% at the end of study. Mean blood glucose level reduced from 194.0 ± 42.5 to 172.9 ± 31.8 mg/dl (P =.0015) measured by CGM. Significant differences were not observed in incidence of overall (P =.7739), diurnal (P =.3701), or nocturnal (P =.5724) hypoglycemia episodes nor in area under the curve (AUC) <54 mg/dl (P =.9528), but a reduction in AUC >180 (P <.01) and AUC >250 (P =.01) was evidenced for total, diurnal, and nocturnal episodes. Conclusions: An intervention consisting of an educational program and a basal-bolus insulin regimen in type 1 and type 2 diabetes mellitus patients undergoing PD caused a decrease in HbA1c levels, and mean blood glucose levels as measured from CGM with no significant increases in hypoglycemia episodes.

Original languageEnglish
Pages (from-to)129-135
Number of pages7
JournalJournal of Diabetes Science and Technology
Volume12
Issue number1
DOIs
StatePublished - 1 Jan 2018
Externally publishedYes

Keywords

  • diabetes mellitus type 1
  • diabetes mellitus type 2
  • hypoglycemia
  • insulin
  • peritoneal dialysis

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