TY - JOUR
T1 - Impact of vaccination against COVID-19 on patients with cancer in ACHOC-C19 study
T2 - Real world evidence from one Latin American country
AU - Ospina, Aylen Vanessa
AU - Brugés, Ricardo
AU - Triana, Iván
AU - Sánchez-Vanegas, Guillermo
AU - Barrero, Angela
AU - Mantilla, William
AU - Ramos, Pedro
AU - Bernal, Laura
AU - Aruachán, Sandra
AU - González, Manuel
AU - Lobatón, José
AU - Quiroga, Alicia
AU - Rivas, Giovanna
AU - González, Guido
AU - Lombana, Milton
AU - Munevar, Isabel
AU - Jiménez, Paola
AU - Avendaño, Ana Cristina
AU - Arias, Mirian Caicedo
AU - López, Carolina
AU - González, Héctor
AU - Pacheco, Javier
AU - Manneh, Ray
AU - Pinilla, Paola
AU - Russi, Andrea
AU - Ortiz, Juan
AU - Insuasty, Jesús
AU - Alcalá, Carmen
AU - Contreras, Fernando
AU - Bogoya, Juliana
N1 - Publisher Copyright:
© The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
PY - 2023
Y1 - 2023
N2 - Introduction: During the pandemic, it has been recommended that vaccination against COVID-19 be a priority for patients with cancer; however, these patients were not included in the initial studies evaluating the available vaccines. Objective: To define the impact of vaccination against COVID-19 in preventing the risk of complications associated with the infection in a cohort of patients with cancer in Colombia. Methods: An analytical observational cohort study, based on national registry of patients with cancer and COVID 19 infection ACHOC-C19, was done. The data was collected from June 2021, until October 2021. Inclusion criteria were: Patients older than 18 years with cancer diagnosis and confirmed COVID-19 infection. Data from the unvaccinated and vaccinated cohorts were compared. Outcomes evaluated included all-cause mortality within 30 days of COVID-19 diagnosis, hospitalization, and need for mechanical ventilation. The estimation of the effect was made through the relative risk (RR), the absolute risk reduction (ARR) and the number needed to treat (NNT). Multivariate analysis was performed using generalized linear models. Results: 896 patients were included, of whom 470 were older than 60 years (52.4%) and 59% were women (n=530). 172 patients were recruited in the vaccinated cohort and 724 in the non-vaccinated cohort (ratio: 1 to 4.2). The cumulative incidence of clinical outcomes among the unvaccinated vs vaccinated patients were: for hospitalization 42% (95% CI: 38.7%-46.1%) vs 29%; (95% CI: 22.4%-36.5%); for invasive mechanical ventilation requirement 8.4% (n=61) vs 4.6% (n=8) and for mortality from all causes 17% (n=123) vs 4.65% (n=8). Conclusion: In our population, unvaccinated patients with cancer have an increased risk of complications for COVID -19 infection, as hospitalization, mechanical ventilation, and mortality. It is highly recommended to actively promote the vaccination among this population.
AB - Introduction: During the pandemic, it has been recommended that vaccination against COVID-19 be a priority for patients with cancer; however, these patients were not included in the initial studies evaluating the available vaccines. Objective: To define the impact of vaccination against COVID-19 in preventing the risk of complications associated with the infection in a cohort of patients with cancer in Colombia. Methods: An analytical observational cohort study, based on national registry of patients with cancer and COVID 19 infection ACHOC-C19, was done. The data was collected from June 2021, until October 2021. Inclusion criteria were: Patients older than 18 years with cancer diagnosis and confirmed COVID-19 infection. Data from the unvaccinated and vaccinated cohorts were compared. Outcomes evaluated included all-cause mortality within 30 days of COVID-19 diagnosis, hospitalization, and need for mechanical ventilation. The estimation of the effect was made through the relative risk (RR), the absolute risk reduction (ARR) and the number needed to treat (NNT). Multivariate analysis was performed using generalized linear models. Results: 896 patients were included, of whom 470 were older than 60 years (52.4%) and 59% were women (n=530). 172 patients were recruited in the vaccinated cohort and 724 in the non-vaccinated cohort (ratio: 1 to 4.2). The cumulative incidence of clinical outcomes among the unvaccinated vs vaccinated patients were: for hospitalization 42% (95% CI: 38.7%-46.1%) vs 29%; (95% CI: 22.4%-36.5%); for invasive mechanical ventilation requirement 8.4% (n=61) vs 4.6% (n=8) and for mortality from all causes 17% (n=123) vs 4.65% (n=8). Conclusion: In our population, unvaccinated patients with cancer have an increased risk of complications for COVID -19 infection, as hospitalization, mechanical ventilation, and mortality. It is highly recommended to actively promote the vaccination among this population.
KW - COVID-19
KW - cancer
KW - cohort studies
KW - hospitalization
KW - mechanical ventilation
KW - mortality
KW - vaccine effectiveness
KW - vaccines
UR - http://www.scopus.com/inward/record.url?scp=85170093751&partnerID=8YFLogxK
U2 - 10.7150/jca.79969
DO - 10.7150/jca.79969
M3 - Artículo
AN - SCOPUS:85170093751
SN - 1837-9664
VL - 14
SP - 2410
EP - 2416
JO - Journal of Cancer
JF - Journal of Cancer
IS - 13
ER -
