Papel protector de la bilirrubina en el ser humano

Translated title of the contribution: The protective role of bilirubin in human beings

William Otero Regino, Héctor Velasco, Héctor Sandoval

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Bilirubin is more than just the final product of heme catabolism. Today it is considered to be a fundamental substance which acts as an antioxidant and anti-inflammatory agent in the serum. It can neutralize free radicals and prevent peroxidation of lipids. In addition there is evidence that it protects the cardiovascular system, neuronal systems, the hepatobiliary system, the pulmonary system and the immune system. Recently the use of pharmacological agents which augment expression of Heme oxygenase 1 (HO-1) has been considered. Consequently its metabolites such as carbon monoxide (CO), biliverdin (BV) and Bilirubin (BR) could become parts of a therapeutic strategy for treatment of various inflammatory illnesses.

Translated title of the contributionThe protective role of bilirubin in human beings
Original languageSpanish
Pages (from-to)293-300
Number of pages8
JournalRevista Colombiana de Gastroenterologia
Issue number3
StatePublished - 2009
Externally publishedYes


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