TY - JOUR
T1 - Population-based multicase-control study in common tumors in Spain (MCC-Spain)
T2 - Rationale and study design
AU - MCC-Spain Study Group
AU - Castaño-Vinyals, Gemma
AU - Aragonés, Nuria
AU - Pérez-Gómez, Beatriz
AU - Martín, Vicente
AU - Llorca, Javier
AU - Moreno, Victor
AU - Altzibar, Jone M.
AU - Ardanaz, Eva
AU - de Sanjosé, Sílvia
AU - Jiménez-Moleón, José Juan
AU - Tardón, Adonina
AU - Alguacil, Juan
AU - Peiró, Rosana
AU - Marcos-Gragera, Rafael
AU - Navarro, Carmen
AU - Pollán, Marina
AU - Kogevinas, Manolis
AU - Alonso, M. T.
AU - Amiano, P.
AU - Arias, C.
AU - Azpiri, M.
AU - Benavente, Y.
AU - Boldo, E.
AU - Bueno, A.
AU - Bustamante, M.
AU - Caballero, F. J.
AU - Campo, E.
AU - Cantón, R.
AU - Capelo, R.
AU - Carmona, C.
AU - Casabonne, D.
AU - Chirlaque, M. D.
AU - Cirac, J.
AU - Clofent, J.
AU - Colado, E.
AU - Costas, L.
AU - Crous, M.
AU - Del Campo, R.
AU - Santos, M. D.
AU - Dierssen-Sotos, T.
AU - Ederra, M.
AU - Espinosa, A.
AU - Cabrera, M. F.
AU - Somoano, A. F.
AU - Villa, T. F.
AU - García-Esquinas, E. G.
AU - Martín, P. G.
AU - Gómez-Acebo, I.
AU - Puga, C. G.
AU - de la Peña, J. J.
N1 - Publisher Copyright:
© 2014 SESPAS.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Introduction: We present the protocol of a large population-based case-control study of 5 common tumors in Spain (MCC-Spain) that evaluates environmental exposures and genetic factors. Methods: Between 2008-2013, 10,183 persons aged 20-85 years were enrolled in 23 hospitals and primary care centres in 12 Spanish provinces including 1,115 cases of a new diagnosis of prostate cancer, 1,750 of breast cancer, 2,171 of colorectal cancer, 492 of gastro-oesophageal cancer, 554 cases of chronic lymphocytic leukaemia (CLL) and 4,101 population-based controls matched by frequency to cases by age, sex and region of residence. Participation rates ranged from 57% (stomach cancer) to 87% (CLL cases) and from 30% to 77% in controls. Participants completed a face-to-face computerized interview on sociodemographic factors, environmental exposures, occupation, medication, lifestyle, and personal and family medical history. In addition, participants completed a self-administered food-frequency questionnaire and telephone interviews. Blood samples were collected from 76% of participants while saliva samples were collected in CLL cases and participants refusing blood extractions. Clinical information was recorded for cases and paraffin blocks and/or fresh tumor samples are available in most collaborating hospitals. Genotyping was done through an exome array enriched with genetic markers in specific pathways. Multiple analyses are planned to assess the association of environmental, personal and genetic risk factors for each tumor and to identify pleiotropic effects. Discussion: This study, conducted within the Spanish Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), is a unique initiative to evaluate etiological factors for common cancers and will promote cancer research and prevention in Spain.
AB - Introduction: We present the protocol of a large population-based case-control study of 5 common tumors in Spain (MCC-Spain) that evaluates environmental exposures and genetic factors. Methods: Between 2008-2013, 10,183 persons aged 20-85 years were enrolled in 23 hospitals and primary care centres in 12 Spanish provinces including 1,115 cases of a new diagnosis of prostate cancer, 1,750 of breast cancer, 2,171 of colorectal cancer, 492 of gastro-oesophageal cancer, 554 cases of chronic lymphocytic leukaemia (CLL) and 4,101 population-based controls matched by frequency to cases by age, sex and region of residence. Participation rates ranged from 57% (stomach cancer) to 87% (CLL cases) and from 30% to 77% in controls. Participants completed a face-to-face computerized interview on sociodemographic factors, environmental exposures, occupation, medication, lifestyle, and personal and family medical history. In addition, participants completed a self-administered food-frequency questionnaire and telephone interviews. Blood samples were collected from 76% of participants while saliva samples were collected in CLL cases and participants refusing blood extractions. Clinical information was recorded for cases and paraffin blocks and/or fresh tumor samples are available in most collaborating hospitals. Genotyping was done through an exome array enriched with genetic markers in specific pathways. Multiple analyses are planned to assess the association of environmental, personal and genetic risk factors for each tumor and to identify pleiotropic effects. Discussion: This study, conducted within the Spanish Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), is a unique initiative to evaluate etiological factors for common cancers and will promote cancer research and prevention in Spain.
KW - Breast cancer
KW - Case-control
KW - Chronic lymphocytic leukemia
KW - Colorectal cancer
KW - Epidemiology
KW - Gastric cancer
KW - Prostate cancer
UR - http://www.scopus.com/inward/record.url?scp=84931569977&partnerID=8YFLogxK
U2 - 10.1016/j.gaceta.2014.12.003
DO - 10.1016/j.gaceta.2014.12.003
M3 - Artículo
C2 - 25613680
AN - SCOPUS:84931569977
SN - 0213-9111
VL - 29
SP - 308
EP - 315
JO - Gaceta Sanitaria
JF - Gaceta Sanitaria
IS - 4
ER -
