TY - JOUR
T1 - Pulmonary involvement in systemic sclerosis
AU - Morales-Cárdenas, Adriana
AU - Pérez-Madrid, Camila
AU - Arias, Liliana
AU - Ojeda, Paulina
AU - Mahecha, María Paula
AU - Rojas-Villarraga, Adriana
AU - Carrillo-Bayona, Jorge A.
AU - Anaya, Juan Manuel
N1 - Publisher Copyright:
© 2016 Elsevier B.V.
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Systemic sclerosis (SSc) is a multi-systemic autoimmune disease that mainly affects the skin, lungs, gastrointestinal tract, heart and kidneys. Pulmonary disease in patients with SSc is strongly associated with mortality. The mechanisms involved into its pathophysiology include the activation of autoimmune cells and hyperplasia of fibroblasts with an increased capacity to produce collagen and diminished collagen breakdown. Although pulmonary biopsy is the gold standard for the diagnosis of interstitial lung disease in SSc, the most commonly used method is high-resolution computed tomography due to its high sensitivity and specificity. Herein, a comprehensive review on the pulmonary involvement in SSc is presented highlighting the radiologic–pathologic correlations.
AB - Systemic sclerosis (SSc) is a multi-systemic autoimmune disease that mainly affects the skin, lungs, gastrointestinal tract, heart and kidneys. Pulmonary disease in patients with SSc is strongly associated with mortality. The mechanisms involved into its pathophysiology include the activation of autoimmune cells and hyperplasia of fibroblasts with an increased capacity to produce collagen and diminished collagen breakdown. Although pulmonary biopsy is the gold standard for the diagnosis of interstitial lung disease in SSc, the most commonly used method is high-resolution computed tomography due to its high sensitivity and specificity. Herein, a comprehensive review on the pulmonary involvement in SSc is presented highlighting the radiologic–pathologic correlations.
KW - Pathology
KW - Pulmonary involvement
KW - Radiology
KW - Systemic sclerosis
KW - Tomography
KW - X-ray computed
UR - http://www.scopus.com/inward/record.url?scp=84992507430&partnerID=8YFLogxK
U2 - 10.1016/j.autrev.2016.07.025
DO - 10.1016/j.autrev.2016.07.025
M3 - Artículo de revisión
C2 - 27497912
AN - SCOPUS:84992507430
SN - 1568-9972
VL - 15
SP - 1094
EP - 1108
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
IS - 11
ER -