Síndromes mielodisplásicos: una actualización para el médico no hematólogo

Translated title of the contribution: Myelodysplastic syndromes: an update for the non-hematologist.

Mario Andrés Hernández-Sómerson, Gustavo Huertas-Rodríguez, Luis David Medina-Lee, Jaime Ortiz-Arroyo, Johanna Pabón-Barrera, Jaime Andrés Escobar-Sáenz

Research output: Contribution to journalArticlepeer-review


Myelodysplastic syndromes comprise a heterogeneous group of neoplasms that affect hematopoietic stem cells, which are related to an increased risk of developing acute myeloid leukemia. Its clinical presentation is highly variable and should be suspected in the presence of persistent cytopenias without clear cause. The cornerstone of the diagnosis is bone marrow biopsy, where dysplastic changes in one or more cell lines, the presence of ringed sideroblasts, the number of blasts and the cytogenetic study make it possible to classify this disease in six different subtypes. Currently, several scores are available to estimate the prognosis leading to an appropriate choice of treatment based on survival and the risk of developing acute myeloid leukemia. This work updates the available literature regarding diagnosis, classification, prognosis systems and treatment of the myelodysplastic syndromes with the objective of providing the non-hematologist with tools that allow early detection and directing the hematologist to a timely treatment.

Translated title of the contributionMyelodysplastic syndromes: an update for the non-hematologist.
Original languageSpanish
Pages (from-to)366-377
Number of pages12
JournalMedicina Interna de Mexico
Issue number2
StatePublished - Mar 2022
Externally publishedYes


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