TY - JOUR
T1 - Serum Adipsin Levels throughout Normal Pregnancy and Preeclampsia
AU - Poveda, Natalia E.
AU - Garcés, María F.
AU - Ruiz-Linares, Carlos E.
AU - Varón, Diana
AU - Valderrama, Sergio
AU - Sanchez, Elizabeth
AU - Castiblanco-Cortes, Adriana
AU - Agudelo-Zapata, Yessica
AU - Sandoval-Alzate, Héctor Fabio
AU - Leal, Luis G.
AU - Ángel-Müller, Edith
AU - Ruíz-Parra, Ariel I.
AU - González-Clavijo, Angélica M.
AU - Diéguez, Carlos
AU - Nogueiras, Rubén
AU - Caminos, Jorge E.
N1 - Funding Information:
We acknowledge grant support from Direccion Nacional de Investigaciones, Vicerrectoria de Investigaciones of the Universidad Nacional de Colombia, COLCIENCIAS Cod. 110154531660, Ministerio de Economia y Competitividad, Xunta de Galicia, CIBERobn, Spain.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Adipsin is a protease produced at high levels by adipose tissue. It is involved in complement activation and metabolic control. The objective of this study was to determine the changes in adipsin levels during different stages of normal pregnancy, and its association with obstetric outcomes, such as preeclampsia. This nested case-control study in a longitudinal cohort included normal pregnant (n = 54) and preeclamptic (n = 18) women, both followed throughout pregnancy. Additionally, some of the normal pregnant women were followed up three months postpartum (n = 18). Healthy non-pregnant women were also studied during their menstrual cycle (n = 20). The results of this study show that in healthy non-pregnant women, adipsin levels did not change significantly during the menstrual cycle. In normal pregnant women, adipsin levels were lower (p < 0.01) when compared with non-pregnant healthy women, but these serum levels increased again during postpartum (p < 0.001). Adipsin levels were significantly elevated in preeclamptic women in late pregnancy (P < 0.01). A significant correlation was not found between leptin and adipsin during the three periods of gestation studied in healthy pregnant and preeclamptic women. Our results suggest that adipsin may be involved in pregnancy-Associated metabolic changes. Moreover, the increase of adipsin levels towards late gestation in preeclamptic women could be related to the pathophysiology of this disease.
AB - Adipsin is a protease produced at high levels by adipose tissue. It is involved in complement activation and metabolic control. The objective of this study was to determine the changes in adipsin levels during different stages of normal pregnancy, and its association with obstetric outcomes, such as preeclampsia. This nested case-control study in a longitudinal cohort included normal pregnant (n = 54) and preeclamptic (n = 18) women, both followed throughout pregnancy. Additionally, some of the normal pregnant women were followed up three months postpartum (n = 18). Healthy non-pregnant women were also studied during their menstrual cycle (n = 20). The results of this study show that in healthy non-pregnant women, adipsin levels did not change significantly during the menstrual cycle. In normal pregnant women, adipsin levels were lower (p < 0.01) when compared with non-pregnant healthy women, but these serum levels increased again during postpartum (p < 0.001). Adipsin levels were significantly elevated in preeclamptic women in late pregnancy (P < 0.01). A significant correlation was not found between leptin and adipsin during the three periods of gestation studied in healthy pregnant and preeclamptic women. Our results suggest that adipsin may be involved in pregnancy-Associated metabolic changes. Moreover, the increase of adipsin levels towards late gestation in preeclamptic women could be related to the pathophysiology of this disease.
UR - http://www.scopus.com/inward/record.url?scp=84957598670&partnerID=8YFLogxK
U2 - 10.1038/srep20073
DO - 10.1038/srep20073
M3 - Artículo
AN - SCOPUS:84957598670
SN - 2045-2322
VL - 6
JO - Scientific Reports
JF - Scientific Reports
M1 - 20073
ER -