Serum galanin levels in young healthy lean and obese non-diabetic men during an oral glucose tolerance test

Héctor Fabio Sandoval-Alzate; Yessica Agudelo-Zapata; Angélica María González-Clavijo; Natalia E. Poveda; Cristian Felipe Espinel-Pachón; Jorge Augusto Escamilla-Castro; Heidy Lorena Márquez-Julio; Hernando Alvarado-Quintero; Fabián Guillermo Rojas-Rodríguez; Juan Manuel Arteaga-Díaz; Javier Hernando Eslava-Schmalbach; Maria Fernanda Garcés-Gutiérrez; Maria Vrontakis; Justo P. Castaño; Raul M. Luque; Carlos Diéguez; Rubén Nogueiras; Jorge E. Caminos

doi:10.1038/srep31661

Serum galanin levels in young healthy lean and obese non-diabetic men during an oral glucose tolerance test

Héctor Fabio Sandoval-Alzate, Yessica Agudelo-Zapata, Angélica María González-Clavijo, Natalia E. Poveda, Cristian Felipe Espinel-Pachón, Jorge Augusto Escamilla-Castro, Heidy Lorena Márquez-Julio, Hernando Alvarado-Quintero, Fabián Guillermo Rojas-Rodríguez, Juan Manuel Arteaga-Díaz, Javier Hernando Eslava-Schmalbach, Maria Fernanda Garcés-Gutiérrez, Maria Vrontakis, Justo P. Castaño, Raul M. Luque, Carlos Diéguez, Rubén Nogueiras, Jorge E. Caminos

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Abstract

Galanin (GAL) is a neuropeptide involved in the homeostasis of energy metabolism. The objective of this study was to investigate the serum levels of GAL during an oral glucose tolerance test (OGTT) in lean and obese young men. This cross-sectional study included 30 obese non-diabetic young men (median 22 years; mean BMI 37 kg/m 2) and 30 healthy lean men (median 23 years; mean BMI 22 kg/m 2). Serum GAL was determined during OGTT. The results of this study include that serum GAL levels showed a reduction during OGTT compared with basal levels in the lean subjects group. Conversely, serum GAL levels increased significantly during OGTT in obese subjects. Serum GAL levels were also higher in obese non-diabetic men compared with lean subjects during fasting and in every period of the OGTT (p < 0.001). Serum GAL levels were positively correlated with BMI, total fat, visceral fat, HOMA-IR, total cholesterol, triglycerides and Leptin. A multiple regression analysis revealed that serum insulin levels at 30, 60 and 120 minutes during the OGTT is the most predictive variable for serum GAL levels (p < 0.001). In conclusion, serum GAL levels are significantly higher in the obese group compared with lean subjects during an OGTT.

Original language	English
Article number	31661
Journal	Scientific Reports
Volume	6
DOIs	https://doi.org/10.1038/srep31661
State	Published - 23 Aug 2016
Externally published	Yes

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Sandoval-Alzate, H. F., Agudelo-Zapata, Y., González-Clavijo, A. M., Poveda, N. E., Espinel-Pachón, C. F., Escamilla-Castro, J. A., Márquez-Julio, H. L., Alvarado-Quintero, H., Rojas-Rodríguez, F. G., Arteaga-Díaz, J. M., Eslava-Schmalbach, J. H., Garcés-Gutiérrez, M. F., Vrontakis, M., Castaño, J. P., Luque, R. M., Diéguez, C., Nogueiras, R., & Caminos, J. E. (2016). Serum galanin levels in young healthy lean and obese non-diabetic men during an oral glucose tolerance test. Scientific Reports, 6, Article 31661. https://doi.org/10.1038/srep31661

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title = "Serum galanin levels in young healthy lean and obese non-diabetic men during an oral glucose tolerance test",

abstract = "Galanin (GAL) is a neuropeptide involved in the homeostasis of energy metabolism. The objective of this study was to investigate the serum levels of GAL during an oral glucose tolerance test (OGTT) in lean and obese young men. This cross-sectional study included 30 obese non-diabetic young men (median 22 years; mean BMI 37 kg/m 2) and 30 healthy lean men (median 23 years; mean BMI 22 kg/m 2). Serum GAL was determined during OGTT. The results of this study include that serum GAL levels showed a reduction during OGTT compared with basal levels in the lean subjects group. Conversely, serum GAL levels increased significantly during OGTT in obese subjects. Serum GAL levels were also higher in obese non-diabetic men compared with lean subjects during fasting and in every period of the OGTT (p < 0.001). Serum GAL levels were positively correlated with BMI, total fat, visceral fat, HOMA-IR, total cholesterol, triglycerides and Leptin. A multiple regression analysis revealed that serum insulin levels at 30, 60 and 120 minutes during the OGTT is the most predictive variable for serum GAL levels (p < 0.001). In conclusion, serum GAL levels are significantly higher in the obese group compared with lean subjects during an OGTT.",

author = "Sandoval-Alzate, {H{\'e}ctor Fabio} and Yessica Agudelo-Zapata and Gonz{\'a}lez-Clavijo, {Ang{\'e}lica Mar{\'i}a} and Poveda, {Natalia E.} and Espinel-Pach{\'o}n, {Cristian Felipe} and Escamilla-Castro, {Jorge Augusto} and M{\'a}rquez-Julio, {Heidy Lorena} and Hernando Alvarado-Quintero and Rojas-Rodr{\'i}guez, {Fabi{\'a}n Guillermo} and Arteaga-D{\'i}az, {Juan Manuel} and Eslava-Schmalbach, {Javier Hernando} and Garc{\'e}s-Guti{\'e}rrez, {Maria Fernanda} and Maria Vrontakis and Casta{\~n}o, {Justo P.} and Luque, {Raul M.} and Carlos Di{\'e}guez and Rub{\'e}n Nogueiras and Caminos, {Jorge E.}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2016.",

year = "2016",

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doi = "10.1038/srep31661",

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Sandoval-Alzate, HF, Agudelo-Zapata, Y, González-Clavijo, AM, Poveda, NE, Espinel-Pachón, CF, Escamilla-Castro, JA, Márquez-Julio, HL, Alvarado-Quintero, H, Rojas-Rodríguez, FG, Arteaga-Díaz, JM, Eslava-Schmalbach, JH, Garcés-Gutiérrez, MF, Vrontakis, M, Castaño, JP, Luque, RM, Diéguez, C, Nogueiras, R & Caminos, JE 2016, 'Serum galanin levels in young healthy lean and obese non-diabetic men during an oral glucose tolerance test', Scientific Reports, vol. 6, 31661. https://doi.org/10.1038/srep31661

TY - JOUR

T1 - Serum galanin levels in young healthy lean and obese non-diabetic men during an oral glucose tolerance test

AU - Sandoval-Alzate, Héctor Fabio

AU - Agudelo-Zapata, Yessica

AU - González-Clavijo, Angélica María

AU - Poveda, Natalia E.

AU - Espinel-Pachón, Cristian Felipe

AU - Escamilla-Castro, Jorge Augusto

AU - Márquez-Julio, Heidy Lorena

AU - Alvarado-Quintero, Hernando

AU - Rojas-Rodríguez, Fabián Guillermo

AU - Arteaga-Díaz, Juan Manuel

AU - Eslava-Schmalbach, Javier Hernando

AU - Garcés-Gutiérrez, Maria Fernanda

AU - Vrontakis, Maria

AU - Castaño, Justo P.

AU - Luque, Raul M.

AU - Diéguez, Carlos

AU - Nogueiras, Rubén

AU - Caminos, Jorge E.

PY - 2016/8/23

Y1 - 2016/8/23

N2 - Galanin (GAL) is a neuropeptide involved in the homeostasis of energy metabolism. The objective of this study was to investigate the serum levels of GAL during an oral glucose tolerance test (OGTT) in lean and obese young men. This cross-sectional study included 30 obese non-diabetic young men (median 22 years; mean BMI 37 kg/m 2) and 30 healthy lean men (median 23 years; mean BMI 22 kg/m 2). Serum GAL was determined during OGTT. The results of this study include that serum GAL levels showed a reduction during OGTT compared with basal levels in the lean subjects group. Conversely, serum GAL levels increased significantly during OGTT in obese subjects. Serum GAL levels were also higher in obese non-diabetic men compared with lean subjects during fasting and in every period of the OGTT (p < 0.001). Serum GAL levels were positively correlated with BMI, total fat, visceral fat, HOMA-IR, total cholesterol, triglycerides and Leptin. A multiple regression analysis revealed that serum insulin levels at 30, 60 and 120 minutes during the OGTT is the most predictive variable for serum GAL levels (p < 0.001). In conclusion, serum GAL levels are significantly higher in the obese group compared with lean subjects during an OGTT.

AB - Galanin (GAL) is a neuropeptide involved in the homeostasis of energy metabolism. The objective of this study was to investigate the serum levels of GAL during an oral glucose tolerance test (OGTT) in lean and obese young men. This cross-sectional study included 30 obese non-diabetic young men (median 22 years; mean BMI 37 kg/m 2) and 30 healthy lean men (median 23 years; mean BMI 22 kg/m 2). Serum GAL was determined during OGTT. The results of this study include that serum GAL levels showed a reduction during OGTT compared with basal levels in the lean subjects group. Conversely, serum GAL levels increased significantly during OGTT in obese subjects. Serum GAL levels were also higher in obese non-diabetic men compared with lean subjects during fasting and in every period of the OGTT (p < 0.001). Serum GAL levels were positively correlated with BMI, total fat, visceral fat, HOMA-IR, total cholesterol, triglycerides and Leptin. A multiple regression analysis revealed that serum insulin levels at 30, 60 and 120 minutes during the OGTT is the most predictive variable for serum GAL levels (p < 0.001). In conclusion, serum GAL levels are significantly higher in the obese group compared with lean subjects during an OGTT.

UR - http://www.scopus.com/inward/record.url?scp=84983542198&partnerID=8YFLogxK

U2 - 10.1038/srep31661

DO - 10.1038/srep31661

M3 - Artículo

C2 - 27550417

AN - SCOPUS:84983542198

SN - 2045-2322

VL - 6

JO - Scientific Reports

JF - Scientific Reports

M1 - 31661

ER -

Serum galanin levels in young healthy lean and obese non-diabetic men during an oral glucose tolerance test

Abstract

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