TY - JOUR
T1 - Tumores germinales gonadales en niños
T2 - Experiencia de 20 años en un centro de referencia pediátrico
AU - Bautista Moreno, Daniel
AU - Ariza-Varon, Michael
AU - Medina-Vega, Derly Lorena
AU - Restrepo-Ángel, Fabio
AU - Linares-Ballesteros, Adriana
AU - Jaramillo, Lina Eugenia
AU - Mendez, Mizrahinn
AU - Molina-Ramirez, Iván Darío
AU - Sarmiento-Urbina, Isabel Cristina
N1 - Publisher Copyright:
© 2015 Universidad Nacional de Colombia. All rights reserved.
PY - 2015
Y1 - 2015
N2 - Background. Germ cell tumors are a heterogeneous group of neoplasms corresponding to 1-3% of pediatric tumors. They usually manifest clinically as testicular mass or abdominal pain. Objective. To make a description of gonadal germ cell tumor types in pediatric referral center in Colombia. Materials and methods. This article takes a retrospective review compiling 20 years of experience in diagnosis and management of these tumors in the Fundación Hospital de La Misericordia. Results. We found 79 patients, 35 men and 44 women, with an average age at diagnosis of 6 years. The teratoma was the most common neoplasia in females and endodermal sinus tumor in men. 70.9% of patients were diagnosed with stage I. In 84,8% measuring tumor markers were obtained. 98.7% were managed with surgery and 58.2% also received chemotherapy, especially BEP protocol. 96% achieved disease remission, 3 patients died. Conclusions. The study shows good results in the management of gonadal germ cell tumors with the established protocol and low recurrence rate in the evaluated period and high rates of children free of disease, were found a low rate of recurrence in the assessment period and high percentage of free of disease.
AB - Background. Germ cell tumors are a heterogeneous group of neoplasms corresponding to 1-3% of pediatric tumors. They usually manifest clinically as testicular mass or abdominal pain. Objective. To make a description of gonadal germ cell tumor types in pediatric referral center in Colombia. Materials and methods. This article takes a retrospective review compiling 20 years of experience in diagnosis and management of these tumors in the Fundación Hospital de La Misericordia. Results. We found 79 patients, 35 men and 44 women, with an average age at diagnosis of 6 years. The teratoma was the most common neoplasia in females and endodermal sinus tumor in men. 70.9% of patients were diagnosed with stage I. In 84,8% measuring tumor markers were obtained. 98.7% were managed with surgery and 58.2% also received chemotherapy, especially BEP protocol. 96% achieved disease remission, 3 patients died. Conclusions. The study shows good results in the management of gonadal germ cell tumors with the established protocol and low recurrence rate in the evaluated period and high rates of children free of disease, were found a low rate of recurrence in the assessment period and high percentage of free of disease.
KW - Biological tumor markers
KW - Children
KW - Germ cells
KW - Gonadal
KW - Gonadectomy (MeSH)
KW - Recurrence
UR - http://www.scopus.com/inward/record.url?scp=84929359680&partnerID=8YFLogxK
U2 - 10.15446/revfacmed.v63n1.44794
DO - 10.15446/revfacmed.v63n1.44794
M3 - Artículo
AN - SCOPUS:84929359680
SN - 0120-0011
VL - 63
SP - 47
EP - 56
JO - Revista Facultad de Medicina
JF - Revista Facultad de Medicina
IS - 1
ER -