Abstract
Introduction: Uric acid has been described as a possible risk marker for the appearance of pre-eclampsia. However, so far there is no solid evidence to support it. The objective of this study is to synthesize the available literature to determine the usefulness of uric acid as a screening tool for pre-eclampsia. Methodology: Systematic review of the literature of primary studies that analyse serum uric acid levels in the first and second trimesters of gestation with the development of pre-eclampsia. Search in PubMed (n: 639). Results: Two studies (2 cohort studies) were included with a total of 9,746 pregnant women and 398 cases of pre-eclampsia. In the studies, higher serum uric acid levels were found in pregnant women who developed preeclampsia (OR 1.8 to 2.0). Conclusions: Uric acid is related to the presence of preeclampsia and its pathophysiology. The scientific community is invited to continue investigating the applicability of uric acid for its implementation as a screening tool in the first and second trimester of pregnancy.
Translated title of the contribution | Ácido úrico herramienta de tamización para preeclampsia. Una revisión sistemática de la literatura |
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Original language | English |
Article number | 100749 |
Journal | Clinica e Investigacion en Ginecologia y Obstetricia |
Volume | 49 |
Issue number | 3 |
DOIs | |
State | Published - 1 Jul 2022 |
Keywords
- Pre-eclampsia
- Screening
- Uric acid
Centers and Institutes Mederi
- Women’s Health Institute