Uric acid screening tool for preeclampsia a systematic review

M. F. Toro Wills, L. C. Sánchez Valencia, V. S. Rangel Ramos, A. M. Pedraza Flechas, M. C. Martínez Ávila

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Uric acid has been described as a possible risk marker for the appearance of pre-eclampsia. However, so far there is no solid evidence to support it. The objective of this study is to synthesize the available literature to determine the usefulness of uric acid as a screening tool for pre-eclampsia. Methodology: Systematic review of the literature of primary studies that analyse serum uric acid levels in the first and second trimesters of gestation with the development of pre-eclampsia. Search in PubMed (n: 639). Results: Two studies (2 cohort studies) were included with a total of 9,746 pregnant women and 398 cases of pre-eclampsia. In the studies, higher serum uric acid levels were found in pregnant women who developed preeclampsia (OR 1.8 to 2.0). Conclusions: Uric acid is related to the presence of preeclampsia and its pathophysiology. The scientific community is invited to continue investigating the applicability of uric acid for its implementation as a screening tool in the first and second trimester of pregnancy.

Translated title of the contributionÁcido úrico herramienta de tamización para preeclampsia. Una revisión sistemática de la literatura
Original languageEnglish
Article number100749
JournalClinica e Investigacion en Ginecologia y Obstetricia
Volume49
Issue number3
DOIs
StatePublished - 1 Jul 2022

Keywords

  • Pre-eclampsia
  • Screening
  • Uric acid

Centers and Institutes Mederi

  • Women’s Health Institute

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